Inhibitory effect of ethanol on the 5-hydroxytryptamine-induced Bezold-Jarisch reflex — involvement of peripheral 5-HT3 receptors

European Journal of Pharmacology: Environmental Toxicology and Pharmacology Pub Date : 1995-05-26 DOI:10.1016/0926-6917(95)90020-9

Barbara Malinowska , Manfred Göthert , Grzegorz Godlewski , Beata Wróbel , Heinz Bönisch , Włodzimierz Buczko

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引用次数: 9

Abstract

The influence of ethanol (0.5, 1.0 and 2.0 g/kg i.p.) on the Bezold-Jarisch reflex in urethane-anesthetized rats was studied. 5-Hydroxytryptamine (serotonin; 5-HT; 1, 3, 10 and 30 μg/kg i.v.) and capsaicin (1, 3 and 10 μg/kg i.v.) reflexly decreased heart rate in a dose-dependent manner. The 5-HT₃ receptor antagonist ondansetron 10 μg/kg i.v. abolished the 5-HT- but not the capsaicin-stimulated bradycardia, indicating that 5-HT and capsaicin acted via different trigger mechanisms (5-HT₃ receptor-dependent and -independent, respectively). Ethanol at 1.0 and 2.0 g/kg i.p. inhibited in a dose-dependent manner (by 20–45%) the 5-HT- but not the capsaicin-stimulated decrease in heart rate. Our results demonstrate that the inhibitory effect of ethanol on the 5-HT₃ receptor-mediated Bezold-Jarisch reflex may be related to the direct effect of ethanol on 5-HT₃ receptors on sensory vagal nerves in the heart.

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乙醇对5-羟色胺诱导的外周5-HT3受体参与Bezold-Jarisch反射的抑制作用

研究了乙醇(0.5、1.0、2.0 g/kg / p)对聚氨酯麻醉大鼠Bezold-Jarisch反射的影响。5 -羟色胺(5 -羟色胺;5;1、3、10和30 μg/kg静脉滴注)和辣椒素(1、3和10 μg/kg静脉滴注)以剂量依赖性方式反射性降低心率。5-HT3受体拮抗剂ondansetron 10 μg/kg静脉注射可消除5-HT刺激的心动过缓，但不能消除辣椒素刺激的心动过缓，表明5-HT和辣椒素通过不同的触发机制起作用(分别为5-HT3受体依赖性和非依赖性)。1.0和2.0 g/kg的乙醇以剂量依赖的方式(20-45%)抑制5-HT-但不抑制辣椒素刺激的心率下降。我们的研究结果表明，乙醇对5-HT3受体介导的Bezold-Jarisch反射的抑制作用可能与乙醇对心脏感觉迷走神经5-HT3受体的直接作用有关。

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European Journal of Pharmacology: Environmental Toxicology and Pharmacology

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