Sub-chronic administration of ethanol to mice does not modify the inhibitory effects of dieldrin, abamectin and the dihydropyrazole RH-3421 at their respective sites of action in the nervous system

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI:10.1016/0742-8413(93)90059-T

Russell A. Nicholson, Margaret F. Williams

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引用次数: 2

Abstract

1. The potential influence of sub-chronic ethanol treatment on the ability of three chemical classes of insecticide to interact with their neuronal sites of action has been investigated in mouse brain.

2. Ethanol administration did not influence the inhibitory effects of either the cyclodiene dieldrin or the avermectin abamectin as determined by inhibition of GABA-stimulated chloride uptake.

3. Likewise there was also no discernable change in the sensitivity of sodium channels to inhibition by dihydropyrazole RH-3421 with sub-chronic ethanol treatment as assessed indirectly using a membrane potential assay.

4. The results of this study indicate that short term dietary exposure to ethanol fails to cause functional changes to the primary target sites of cyclodienes, avennectins and dihydropyrazoles in the mammalian central nervous system.

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小鼠亚慢性给药乙醇不改变狄氏剂、阿维菌素和二氢吡唑RH-3421在神经系统中各自作用部位的抑制作用

1. 在小鼠脑中研究了亚慢性乙醇处理对三种化学杀虫剂与其作用神经元位点相互作用能力的潜在影响。乙醇对环二烯狄氏剂和阿维菌素的抑制作用没有影响，这是通过抑制gaba刺激的氯化物摄取来确定的。同样，用膜电位法间接评估，在亚慢性乙醇处理下，钠通道对二氢吡唑RH-3421抑制的敏感性也没有明显的变化。本研究结果表明，短期饮食暴露于乙醇不会引起哺乳动物中枢神经系统环二烯、avennectins和二氢吡唑主要靶点的功能改变。

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Comparative biochemistry and physiology. C: Comparative pharmacology

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