{"title":"Endothelin regulates PGE2 formation in rat mesangial cells through induction of prostaglandin endoperoxide synthase-2.","authors":"E Coroneos, M Kester, P Thomas, M J Dunn","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Endothelin-1 stimulates vascular smooth muscle and mesangial cells to release prostaglandin E2 which attenuates the vasoconstrictor and mitogenic effects of endothelin. The role of endothelin-1 to regulate prostaglandin endoperoxide synthase (PGHS)-1 and -2 gene expression and protein synthesis was evaluated in cultured mesangial cells. Endothelin induced mRNA and protein expression for PGHS-2 but not for PGHS-1. A direct correlation was observed between the mass of immunoprecipitated PGHS protein and PGE2 synthetic enzymatic activity.</p>","PeriodicalId":7381,"journal":{"name":"Advances in prostaglandin, thromboxane, and leukotriene research","volume":"23 ","pages":"117-9"},"PeriodicalIF":0.0000,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in prostaglandin, thromboxane, and leukotriene research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Endothelin-1 stimulates vascular smooth muscle and mesangial cells to release prostaglandin E2 which attenuates the vasoconstrictor and mitogenic effects of endothelin. The role of endothelin-1 to regulate prostaglandin endoperoxide synthase (PGHS)-1 and -2 gene expression and protein synthesis was evaluated in cultured mesangial cells. Endothelin induced mRNA and protein expression for PGHS-2 but not for PGHS-1. A direct correlation was observed between the mass of immunoprecipitated PGHS protein and PGE2 synthetic enzymatic activity.
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