Ethnic and genetic differences in susceptibility to osteoporotic fractures.

Abstract

A plethora of investigations in recent years has demonstrated the occurrence of ethnic differences in bone mineral content, bone density and fracture rates. These findings indicate that genetic determinants exist both for bone development during growth and for bone loss during aging. Twin and parent-offspring studies have corroborated the existence of a hereditary component. It is most evident in the greater bone mass and lower fracture rate in blacks than in whites. Differences in bone mass between Asians and whites are less clear than between blacks and whites because of disparities in body size and other confounding factors. Black children and adults excrete less urinary calcium than whites on essentially the same diets and consequently retain more calcium in their skeletons. Better calcium retention is commensurate with the faster rate of bone growth of black children.