Antagonism by paraquat of the relaxing effects of acetylcholine and A23187 in rat thoracic aorta

Kuei-Sen Hsu, Shoei-Yn Lin-Shiau
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引用次数: 8

Abstract

Paraquat, a widely used herbicide, has been reported to be capable of producing superoxide. In the present paper, therefore, the possibility of paraquat inhibiting endothelium-dependent relaxation, mediated by the production of nitric oxide, was tested. The relaxing effects of acetylcholine and A23187, but not that of sodium nitroprusside, in the rat thoracic aorta were found to be inhibited by paraquat in a concentration-dependent manner. In contrast, paraquat was totally inactive with regard to the aortic contractions induced by either norepinephrine or prostaglandin F. The inhibitory action of paraquat could be antagonized by superoxide dismutase but not by catalase and indomethacin. All of these findings indicate that superoxide anions produced by paraquat in the endothelium contribute to a decrease in the relaxation response to acetylcholine and A23187 by interfering with endothelium-derived nitric oxide.

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百草枯对大鼠胸主动脉乙酰胆碱和A23187舒张作用的拮抗作用
据报道,广泛使用的除草剂百草枯能够产生超氧化物。因此,在本文中,测试了百草枯抑制由一氧化氮产生介导的内皮依赖性松弛的可能性。在大鼠胸主动脉中,乙酰胆碱和A23187的舒张作用被百草枯呈浓度依赖性地抑制,而硝普钠的舒张作用不受影响。相比之下,百草枯对去甲肾上腺素或前列腺素F2α诱导的主动脉收缩完全无效。百草枯的抑制作用可被超氧化物歧化酶拮抗,但不能被过氧化氢酶和吲哚美辛拮抗。所有这些结果表明,百草枯在内皮中产生的超氧阴离子通过干扰内皮源性一氧化氮,有助于降低对乙酰胆碱和A23187的松弛反应。
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