[Prevention of macroangiopathy of type 2 diabetes in clinical practice].

Diabete & metabolisme Pub Date : 1994-11-01
B Charbonnel, C Laurent
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Abstract

The increase in cardio-vascular morbidity of people with Type 2 diabetes is due to the frequent association of Type 2 diabetes with classical risk factors but also to diabetes per se, whatever the mechanisms involved. From a clinical point of view, it is important to stop smoking, with a great benefit, to treat hypertension with other drugs than diuretics or beta-blockers and to treat dyslipidaemia. The lipid abnormalities often improve with the only glycaemic control. In all cases, the normalisation of HbA1c is a very important therapeutic goal, by diet, exercise, oral hypoglycaemic drugs or insulin if necessary. The treatment will be especially useful in high risk patients, i.e. patients with coronary heart disease, patients with albuminuria, patients with more than 3 risk factors associated with diabetes and/or with high glycaemic levels.

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[2型糖尿病大血管病变的临床预防]。
2型糖尿病患者心血管疾病发病率的增加是由于2型糖尿病与经典危险因素的频繁关联,但也与糖尿病本身有关,无论其机制如何。从临床的角度来看,重要的是戒烟,用利尿剂或-受体阻滞剂以外的其他药物治疗高血压,治疗血脂异常。脂质异常通常在唯一的血糖控制下得到改善。在所有情况下,HbA1c的正常化都是一个非常重要的治疗目标,可以通过饮食、运动、口服降糖药或必要时使用胰岛素来实现。该疗法对高危患者特别有用,如冠心病患者、蛋白尿患者、伴有3种以上与糖尿病相关的危险因素的患者和/或高血糖水平患者。
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