Deiodination of thyroid hormones. A 30 year perspective (Berthold Memorial Award Lecture 1994).

L E Braverman
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引用次数: 16

Abstract

It is truly a great honor to be the 1994 recipient of the Berthold Memorial Award from the German Endocrine Society which met in Würzburg, March 2-5. I am especially indebted to Drs. Köhrle and Wuttke for their kindness in making our visit to Würzburg so enjoyable and educational. Professor Berthold was the first to demonstrate the effects of a hormone on phenotypic expression when he transplanted testes to a castrated rooster, restoring its masculine appearance and behavior (Figure 1) (Berthold, 1849). Since 1960, when I joined the laboratory of the late Dr. Sidney H. Ingbar at the Thorndike Memorial Laboratory at the Boston City Hospital and Harvard Medical School, one of our major interest has been the peripheral metabolism of the thyroid hormones (Figure 2), especially the deiodination pathway (Figure 3). This review will be primarily based on our studies, although many other laboratories have made extremely important observations on thyroid hormone metabolism at the clinical, physiological, and molecular biological levels. I am indebted to many collaborators who have played major roles in many of the studies to be cited in this review. The principle colleagues are listed in Table 1. Since much of our work has been carried out simultaneously in rats, humans, and cell cultures, studies will be described under these three broad categories.

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甲状腺激素的脱碘一个30年的视角(Berthold纪念奖演讲1994)。
我非常荣幸能获得1994年德国内分泌学会颁发的贝特霍尔德纪念奖,该学会于3月2-5日在德国维尔茨堡举行了会议。我特别感谢dr。Köhrle和Wuttke,感谢他们的好意,让我们对w茨堡的访问如此愉快和有教育意义。Berthold教授是第一个证明激素对表型表达影响的人,他将睾丸移植到一只被阉割的公鸡身上,恢复了它的男性外观和行为(图1)(Berthold, 1849)。自1960年我加入波士顿城市医院桑代克纪念实验室和哈佛医学院已故Sidney H. Ingbar博士的实验室以来,我们的主要兴趣之一是甲状腺激素的外周代谢(图2),特别是脱碘途径(图3)。尽管许多其他实验室已经在临床上对甲状腺激素代谢进行了非常重要的观察,但本文将主要基于我们的研究。生理和分子生物学水平。我要感谢许多合作者,他们在本综述中引用的许多研究中发挥了重要作用。主要同事列于表1。由于我们的大部分工作都是在大鼠、人类和细胞培养中同时进行的,因此研究将在这三大类下进行描述。
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