Diacylglycerol: Formation and function in phospholipid-mediated signal transduction

E.W. Haeffner
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引用次数: 6

Abstract

1. Properties, distribution and multiplicity of phosphoinositidases (phospholipase C, PLC) are investigated.

2. Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined.

3. Ca2+ and phospholipid-dependent protein kinase C act as the target of DAG messenger action.

4. There are differences in the formation of DAG in normal and transformal cell.

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二酰基甘油:磷脂介导的信号转导的形成和功能
1. 研究了磷脂酶C (phospholipase C, PLC)的性质、分布和多样性。二酰基甘油(DAG)的生成由多种酶,如磷脂肌肽和磷脂酰胆碱特异性PLC,磷脂酶D和磷脂水解酶的组合,以及甘油三酯脂肪酶检查。Ca2+和磷脂依赖性蛋白激酶C作为DAG信使作用的靶点。在正常细胞和转化细胞中DAG的形成有差异。
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