Prediction of gestational hypertension by cosinor analysis of second trimester blood pressure.

Chronobiologia Pub Date : 1994-01-01
A L Tranquilli, C Conti, B Rezai, G G Garzetti, C Romanini
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Abstract

Objective: We evaluated the efficacy of cosinor analysis of blood pressure (BP) at the second trimester in predicting the subsequent development of gestational hypertension.

Study design: We performed the cosinor analysis of BP in 313 normotensive non-proteinuric nulliparous women at the second trimester. We followed the pregnancy up to delivery and recorded the subsequent occurrence of gestational hypertension (sGH). We compared data from this group of 33 patients with those from the 280 women with uncomplicated normotensive pregnancy. We used the ANOVA to compare the means, statistical significance was assessed at p < .05.

Results: Diastolic MESOR of women with uncomplicated pregnancy was significantly lower than the GH patients, although both groups were definitely normotensive at the time of the recording. (Diastolic: Controls M = 62.2 +/- 1.5, A = 5.1 +/- 0.7, O = 14:07, p = .0001; sGH M = 73.5 +/- 6.2m, A = 5.9 +/- 1.1, O = 14:48, p = .003; Systolic: Controls M = 108.3 +/- 2.2, A = 5.2 +/- 0.7, O = 15:00, p = .0001; sGH M = 122.4 +/- 2.1, A = 4.1 +/- 0.8, O = 15:59, p = .01) We did not find any other significant difference among the population-mean cosinors. The most sensitive cutoff of diastolic blood pressure MESOR proved to be 68 mmHg.

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孕中期血压余弦分析预测妊娠期高血压。
目的:评价孕中期血压余弦分析在预测妊娠高血压后续发展中的作用。研究设计:我们对313名妊娠中期血压正常、无蛋白尿的产妇进行了血压余弦分析。我们跟踪妊娠至分娩并记录妊娠期高血压(sGH)的发生情况。我们将这33名患者的数据与280名无并发症的正常妊娠妇女的数据进行了比较。采用方差分析比较均数,p < 0.05为差异有统计学意义。结果:无并发症妊娠妇女的舒张MESOR明显低于GH患者,尽管两组在记录时血压都是正常的。(舒张:对照组M = 62.2 +/- 1.5, A = 5.1 +/- 0.7, O = 14:07, p = 0.0001;功能减退M = 73.5 + / - 6.2 M, A = 5.9 + / - 1.1, O = 48, p = .003;收缩期:对照组M = 108.3 +/- 2.2, A = 5.2 +/- 0.7, O = 15:00, p = 0.0001;sGH M = 122.4 +/- 2.1, A = 4.1 +/- 0.8, O = 15:59, p = 0.01)我们没有发现其他显著差异。MESOR最敏感的舒张压临界值为68 mmHg。
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