Bakers' asthma caused by alpha amylase.

Annals of allergy Pub Date : 1994-10-01
R Valdivieso, J Subiza, J L Subiza, M Hinojosa, E de Carlos, E Subiza
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引用次数: 0

Abstract

Two bakers with bronchial asthma and two with rhinoconjunctivitis are described. Prick and RAST tests were positive with wheat flour in all of them, but the challenge test (nasal or bronchial) with wheat flour extract was positive only in one asthmatic baker. The prick test, RAST, and nasal or bronchial challenge done with alpha amylase extract (a glycolytic enzyme obtained from Aspergillus oryzae and used as a flour additive) were positive in all four patients. Our results support previous data indicating that alpha amylase used in bakeries is an important antigen that could cause respiratory allergy in bakers. It can function as sole causative allergen or in addition with other allergens used in the baking industry.

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淀粉酶引起的贝克氏哮喘。
两个面包师与支气管哮喘和两个与鼻结膜炎描述。小麦粉的刺破和RAST试验均呈阳性,而小麦粉提取物的鼻腔或支气管激发试验仅1例呈阳性。用α淀粉酶提取物(一种从米曲霉中提取的糖酵解酶,用作面粉添加剂)进行的点刺试验、RAST和鼻腔或支气管攻击在所有4例患者中均呈阳性。我们的研究结果支持了之前的数据,表明面包店中使用的α淀粉酶是一种重要的抗原,可能导致面包师呼吸道过敏。它可以作为唯一的致敏原,也可以与烘焙工业中使用的其他致敏原一起使用。
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