Lumbar vertebral and femoral neck bone mineral density are higher in postmenopausal women with the α2HS-glycoprotein 2 phenotype

Ian R. Dickson , Rhian Gwilliam , Mary Arora , Sean Murphy , Kay-Tee Khaw , Christopher Phillips , Patrick Lincoln
{"title":"Lumbar vertebral and femoral neck bone mineral density are higher in postmenopausal women with the α2HS-glycoprotein 2 phenotype","authors":"Ian R. Dickson ,&nbsp;Rhian Gwilliam ,&nbsp;Mary Arora ,&nbsp;Sean Murphy ,&nbsp;Kay-Tee Khaw ,&nbsp;Christopher Phillips ,&nbsp;Patrick Lincoln","doi":"10.1016/S0169-6009(08)80135-3","DOIUrl":null,"url":null,"abstract":"<div><p><em>α</em><sub>2</sub>HS-glycoprotein (AHSG) is a plasma protein which becomes concentrated in the organic matrix of bone. The two most common alleles, AHSG<sup>*</sup>1 and AHSG<sup>*</sup>2, give rise to three common phenotypes. A recent report showed that a group of postmenopausal white North American women with different AHSG phenotypes differed significantly with respect to their oestrogen status. We have studied variations in bone mineral density, measured by DEXA, and levels of sex hormones and biochemical markers of bone metabolism in a group of 88 post-menopausal women unselected as to their health status. Lumbar vertebral and femoral neck bone mineral density (BMD), and the free oestradiol index were all significantly higher (<em>P</em> &lt; 0.05) in women with the AHSG 2 phenotype. Values of these three parameters were lowest in the AHSG 1 phenotype and intermediate in the AHSG 2−1 phenotype. Because the differences in BMD between the AHSG 2 and 1 phenotypes represent at least a 40% difference in fracture risk, the AHSG phenotype may be of some clinical relevance as a risk factor for osteoporosis.</p></div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"24 3","pages":"Pages 181-188"},"PeriodicalIF":0.0000,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80135-3","citationCount":"32","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bone and mineral","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169600908801353","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 32

Abstract

α2HS-glycoprotein (AHSG) is a plasma protein which becomes concentrated in the organic matrix of bone. The two most common alleles, AHSG*1 and AHSG*2, give rise to three common phenotypes. A recent report showed that a group of postmenopausal white North American women with different AHSG phenotypes differed significantly with respect to their oestrogen status. We have studied variations in bone mineral density, measured by DEXA, and levels of sex hormones and biochemical markers of bone metabolism in a group of 88 post-menopausal women unselected as to their health status. Lumbar vertebral and femoral neck bone mineral density (BMD), and the free oestradiol index were all significantly higher (P < 0.05) in women with the AHSG 2 phenotype. Values of these three parameters were lowest in the AHSG 1 phenotype and intermediate in the AHSG 2−1 phenotype. Because the differences in BMD between the AHSG 2 and 1 phenotypes represent at least a 40% difference in fracture risk, the AHSG phenotype may be of some clinical relevance as a risk factor for osteoporosis.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
α 2hs -糖蛋白2表型的绝经后妇女腰椎和股骨颈骨密度较高
α 2hs -糖蛋白(AHSG)是一种血浆蛋白,在骨的有机基质中富集。两个最常见的等位基因AHSG*1和AHSG*2产生三种常见的表型。最近的一份报告显示,一组绝经后的北美白人女性具有不同的AHSG表型,其雌激素水平有显著差异。我们研究了骨矿物质密度的变化,通过DEXA测量,性激素水平和骨代谢的生化标志物在一组88绝经后妇女的健康状况未被选择。腰椎、股骨颈骨密度(BMD)、游离雌二醇指数均显著升高(P <0.05)。这三个参数的值在AHSG 1表型中最低,在AHSG 2−1表型中居中。由于AHSG 2型和1型骨密度的差异在骨折风险上至少有40%的差异,因此AHSG表型可能作为骨质疏松症的危险因素具有一定的临床相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Selected bibliography. Socio-economic status and fertility decline: Insights from historical transitions in Europe and North America. Subject index Author index Author index
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1