Splenic rupture in hemophilia.

D W Fort, J C Bernini, A Johnson, C J Cochran, G R Buchanan
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引用次数: 16

Abstract

Purpose: Little information is available regarding splenic injury in patients with hemophilia. We describe here the management of splenic rupture in five of our patients with hemophilia and summarize the literature describing this complication.

Patients and methods: Two human immunodeficiency virus-seropositive patients were managed medically and did not require splenectomy. A third patient had a high titer inhibitor to both porcine and human factor VIII and required emergency splenectomy. Two boys had not been previously diagnosed with hemophilia until they underwent splenectomy after abdominal trauma.

Results: All five patients survived.

Conclusions: These cases demonstrate that nonsurgical management of splenic injury in patients with hemophilia can be performed safely and that splenectomy can be successfully performed despite a high titer of factor VIII inhibitor.

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血友病的脾破裂。
目的:关于血友病患者脾损伤的信息很少。我们在此描述5例血友病患者脾破裂的处理,并总结描述这种并发症的文献。患者和方法:2例人类免疫缺陷病毒血清阳性患者接受医学治疗,不需要脾切除术。第三例患者对猪和人因子VIII均有高滴度抑制剂,需要紧急脾切除术。两名男孩在腹部创伤后接受脾切除术前未被诊断为血友病。结果:5例患者全部存活。结论:这些病例表明,血友病患者脾损伤的非手术治疗可以安全进行,脾切除术可以成功进行,尽管有高滴度的因子VIII抑制剂。
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