{"title":"Trichosanthin as an abortifacient for terminating early pregnancy in mice.","authors":"W Y Chan, T B Ng, H W Yeung","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To test trichosanthin--a basic protein from Trichosanthes kirilowii--as abortifacient, and effect on subsequent pregnancy.</p><p><strong>Methods: </strong>Female mice, on day 1, 2, or 3 of pregnancy, given 0.10, 0.15, 0.20, or 0.25 mg/25 g body wt., intraperitoneally. Animals killed on day 11 for assessment of abortion, or day 4 for examination of embryos. Subsequent pregnancy was tested after 20 days in mice that had aborted completely.</p><p><strong>Results: </strong>With 0.20-0.25 mg/25 g, 64-80% aborted. At day 4, pre-implantation development was disturbed, many still being morulae (in the oviduct). Subsequent pregnancies and offspring were entirely normal.</p><p><strong>Conclusions: </strong>Trichosanthin, long used to effect abortion in humans in China, has congruent effects on ICR laboratory mice.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"38 2","pages":"99-107"},"PeriodicalIF":0.0000,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Fertility","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To test trichosanthin--a basic protein from Trichosanthes kirilowii--as abortifacient, and effect on subsequent pregnancy.
Methods: Female mice, on day 1, 2, or 3 of pregnancy, given 0.10, 0.15, 0.20, or 0.25 mg/25 g body wt., intraperitoneally. Animals killed on day 11 for assessment of abortion, or day 4 for examination of embryos. Subsequent pregnancy was tested after 20 days in mice that had aborted completely.
Results: With 0.20-0.25 mg/25 g, 64-80% aborted. At day 4, pre-implantation development was disturbed, many still being morulae (in the oviduct). Subsequent pregnancies and offspring were entirely normal.
Conclusions: Trichosanthin, long used to effect abortion in humans in China, has congruent effects on ICR laboratory mice.
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