{"title":"The effects of synthetic thymopoietin on binding of α-bungarotoxin to rat neural membranes","authors":"K.R. Jennings , H.M. Shieh","doi":"10.1016/0742-8413(93)90010-I","DOIUrl":null,"url":null,"abstract":"<div><p>Chemically synthesized bovine thymopoietin I (TPO-I) and thymopoietin II (TPO-II) were evaluated as inhibitors of <sup>125</sup>I α-Bungarotoxin binding to rat brain neural membranes and found to be over 1,000 × less potent (<span><math><mtext>IC</mtext><msub><mi></mi><mn>50</mn></msub><mtext> = 10μ</mtext><mtext>M</mtext></math></span>) than reported for thymopoietin isolated from bovine thymus.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"104 3","pages":"Pages 411-413"},"PeriodicalIF":0.0000,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90010-I","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/074284139390010I","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Chemically synthesized bovine thymopoietin I (TPO-I) and thymopoietin II (TPO-II) were evaluated as inhibitors of 125I α-Bungarotoxin binding to rat brain neural membranes and found to be over 1,000 × less potent () than reported for thymopoietin isolated from bovine thymus.
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