Effect of bovine bone morphogenetic protein and bioactive glass on demineralized bone matrix grafts in the rat muscular pouch.

K J Pajamäki, O H Andersson, T S Lindholm, K H Karlsson, A Yli-Urpo, R P Happonen
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引用次数: 0

Abstract

New bone formation induced by allogeneic demineralized bone matrix (DBM) and bone morphogenetic protein (BMP) combined with bioactive glass (BG) was studied in a rat abdominal muscle pouch model. At four weeks the amount of new bone was not influenced by DBM combined with BMP and/or bioactive glass. The mean proportional areas of new bone varied among different DBM test groups from 8.6% to 13.4%. New bone was induced in inactivated DBM samples containing BG, while no bone formation was seen in DBM samples without BG. The results indicate that bioactive glass favours bone induction in inactivated allogeneic bone matrix.

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牛骨形态发生蛋白和生物活性玻璃对大鼠肌袋脱矿骨基质移植物的影响。
研究了同种异体脱矿骨基质(DBM)和骨形态发生蛋白(BMP)联合生物活性玻璃(BG)在大鼠腹肌袋模型中诱导新骨形成的作用。四周时,DBM联合BMP和/或生物活性玻璃对新骨的数量没有影响。不同DBM试验组的平均新骨比例面积从8.6%到13.4%不等。含BG的失活DBM可诱导新骨形成,不含BG的DBM未见骨形成。结果表明,生物活性玻璃有利于失活异体骨基质的骨诱导。
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