Evolution of the transforming growth factor-beta superfamily

Progress in growth factor research Pub Date : 1994-01-01 DOI:10.1016/0955-2235(94)90020-5

David W. Burt, Andrew S. Law

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引用次数: 126

Abstract

Transforming growth factor β1 (TGF-β1) is the prototype of an increasingly complex superfamily of growth and differentiation factors. To date, a total of 74 TGF-β-like sequences have been published, probably representing 23 distinct genes. These sequences were obtained from mammalian, avian, amphibian and insect species, thus emphasising the ancient nature of the TGF-β superfamily peptides. This article summarises current hypotheses concerning the evolutionary history of this protein superfamily, based on the molecular phylogeny of the published sequences. Comparison of the deduced amino acid sequences leads to the definition of five main groups within the superfamily (TGF-β, Bone Morphogenetic Proteins [BMP], Anti-Müllerian Hormone [AMH], Inhibin α [INHα] and GDF-9) and six subgroups within the BMPs (60A, Decapentaplegic [ddp], Vg1, BMP-3, Inhibin β [ $INHβ_{AB}$ ] and nodal). This classification predicts possible phylogenetic and functional relationships among these proteins.

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转化生长因子- β超家族的进化

转化生长因子β1 (TGF-β1)是一个日益复杂的生长分化因子超家族的原型。迄今为止，共发表了74个TGF-β样序列，可能代表23个不同的基因。这些序列来自哺乳动物、鸟类、两栖动物和昆虫物种，从而强调了TGF-β超家族肽的古老性质。本文基于已发表序列的分子系统发育，总结了目前关于该蛋白超家族进化史的假设。通过比较推断出的氨基酸序列，确定了该超家族中的5个主要类群(TGF-β、骨形态发生蛋白(BMP)、抗勒氏激素(AMH)、抑制素α (INHα)和GDF-9)和BMP中的6个亚群(60A、Decapentaplegic [ddp]、Vg1、BMP-3、抑制素β (INHβAB)和nodal)。这种分类预测了这些蛋白质之间可能的系统发育和功能关系。

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