Neonatal hemochromatosis associated with maternal autoantibodies against Ro/SS-A and La/SS-B ribonucleoproteins.

J Schoenlebe, J P Buyon, B J Zitelli, D Friedman, M A Greco, A S Knisely
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引用次数: 59

Abstract

Liver disease in the fetus and neonate may be associated with maternal Sjögren's syndrome (neonatal lupus erythematosus). The infant of a mother with Sjögren's syndrome and high anti-Ro/SS-A and anti-La/SS-B antibody titers presented at 2 1/2 weeks of age with overwhelming hepatic insufficiency and died at 6 weeks of age. Autopsy confirmed the antemortem diagnosis of neonatal hemochromatosis. We discuss the possibility of a relationship between these two conditions.

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新生儿血色素沉着症与母体针对Ro/SS-A和La/SS-B核糖核蛋白的自身抗体有关。
胎儿和新生儿的肝脏疾病可能与母亲的斯约格伦综合征(新生儿红斑狼疮)有关。一名母亲患有 Sjögren's 综合征和高抗 Ro/SS-A 和抗 La/SS-B 抗体滴度的婴儿在 2 周半大时出现肝功能不全,并在 6 周大时死亡。尸检证实了新生儿血色病的死前诊断。我们讨论了这两种病症之间可能存在的关系。
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