Prevalence and risk factors for chronic bronchitis and farmer's lung in French dairy farmers.

J C Dalphin, D Debieuvre, D Pernet, M F Maheu, J C Polio, B Toson, A Dubiez, E Monnet, J J Laplante, A Depierre
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引用次数: 98

Abstract

The prevalence of chronic bronchitis and of clinical farmer's lung was studied in 30 districts of the French Doubs province in relation to individual (age, sex, smoking) and geographical (altitude) factors. 5703 exclusively dairy farmers (response rate 83%) participated in the study by answering a medical questionnaire. Prevalences of chronic bronchitis and clinical farmer's lung were 9.3% and 1.4% respectively. A logistic regression model was used to evaluate risk factors for chronic bronchitis and clinical farmer's lung. A risk of chronic bronchitis was associated with male sex (p < 10(-4)), age (p < 10(-4)), smoker category (p < 10(-4)), and altitude (p < 10(-4)). A risk of clinical farmer's lung was associated with non-smokers (p < 0.05), and linearly with altitude (p < 10(-4)). Also there was a strong positive relation between chronic bronchitis and clinical farmer's lung (odds ratio 19.5 (95% confidence interval 12.1-31.4) after adjustment for confounding variables. The main finding of this study is the highly significant increase of prevalence of the diseases in relation to altitude.

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法国奶农慢性支气管炎和农民肺的患病率及危险因素。
研究了法国杜布省30个地区慢性支气管炎和临床农民肺的患病率与个人(年龄、性别、吸烟)和地理(海拔)因素的关系。5703名纯奶农(回复率83%)通过回答医学问卷参与了研究。慢性支气管炎和临床农民肺的患病率分别为9.3%和1.4%。采用logistic回归模型评价慢性支气管炎和临床农民肺的危险因素。患慢性支气管炎的风险与男性(p < 10(-4))、年龄(p < 10(-4))、吸烟类型(p < 10(-4))和海拔(p < 10(-4))有关。临床农民肺风险与不吸烟者相关(p < 0.05),与海拔高度呈线性关系(p < 10(-4))。在校正混杂变量后,慢性支气管炎与临床农民肺有很强的正相关(优势比19.5(95%可信区间12.1-31.4))。本研究的主要发现是与海拔高度相关的疾病患病率显著增加。
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