The disposition and metabolism of methyl acrylate in male Wistar albino rats.

Abstract

The present study was designed to investigate methyl-[2,3-14C]acrylate (MA) distribution, excretion, and metabolism. Data presented here show that the radioactivity derived from MA is rapidly absorbed after i.p. and p.o. administration and distributed into all major tissues of rats. The highest concentration of MA-derived radioactivity was detected mainly in the liver and kidneys at 1 (i.p.) or 2 (p.o.) hours after dosing. There were only slight differences observed in the dynamics of tissue distribution and excretion in relation to the route of administration. The major route of MA excretion was CO2 exhalation (approximately 54% of the administered dose in 48 h) followed by urinary excretion. Two metabolites were identified in the urine, namely, N-acetyl-S-(2-methylcarboxyethyl)cysteine and N-acetyl-S-(2-carboxyethyl)cysteine, and ratio between those was about 1:1.