T Sasajima, K Mineura, N Kuwahara, M Kowada, M Murakami, K Uemura
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Abstract
To elucidate metabolic pathways of methionine in brain tumors, we studied autoradiographic images of (14C-methyl)-L-methionine (14C-Met) in transplanted rat brain tumors. 14C-Met accumulated in the tumor almost twice as much as in the gray matter 90 min after injection. The acid-insoluble fraction, which was bound to macromolecules, comprised 84% the total count of the accumulated tracers in the tumor. Analysis of 14C-Met tracer accumulation is informative for understanding amino acid metabolism in brain tumors.
为了阐明蛋氨酸在脑肿瘤中的代谢途径，我们研究了移植大鼠脑肿瘤中(14c -甲基)- l -蛋氨酸(14C-Met)的放射自显像。注射后90分钟，肿瘤内14C-Met的积累量几乎是灰质内14C-Met的两倍。与大分子结合的酸不溶性部分占肿瘤中累积示踪剂总数的84%。分析14C-Met示踪剂积累有助于了解脑肿瘤中的氨基酸代谢。
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