Relationship between the monoamine and gonadotropin content in follicular fluid of preovulatory graafian follicles after superovulation treatment.

J Bódis, G Hartmann, A Török, Z Bognár, H R Tinneberg, P Cledon, V Hanf
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引用次数: 27

Abstract

Noradrenaline (NA), serotonin (5HT), dopamine (DA), FSH, LH and prolactin (PRL) content was determined in 104 preovulatory follicular fluids obtained from 44 patients undergoing in vitro fertilization. The patients were given human menopausal gonadotropin (HMG) for ovarium stimulation, ovulation was induced with 10000 IU human chorionic gonadotropin (HCG) 34-36 hours prior to the follicular aspiration by vaginal ultrasound. Classification of the oocytes was performed by direct microscopic evaluation differentiating three groups of oocytes: Group I.: prophase I; Group II.: metaphase I; Group III.: metaphase II. There was no significant difference in monoamine and FSH content of follicular fluid at different stage of the oocyte maturation. LH and PRL significantly increased parallel with oocyte maturation (38.9; 48.8; 56.7 IU/l and 1324; 2382; 3134 IU/l). significant negative correlation was observed in Group I. between 5HT-LH (r = -0.64); in Group II. between NA-LH (r = -0.62) and NA-PRL (r = -0.51). Significant positive correlation were found in Group I. between FSH-LH (r = 0.63), in Group II. between LH-PRL (r = 0.56), in Group III. between NA-5HT (r = 0.66), NA-DA (r = 0.80) and 5HT-DA (r = 0.66). These observations suggest that action of LH and PRL may be negatively modulated by 5HT and NA in the final stage of oocyte maturation.

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超排卵治疗后卵泡液单胺与促性腺激素含量的关系
对44例体外受精患者的104份排卵前卵泡液进行去甲肾上腺素(NA)、血清素(5HT)、多巴胺(DA)、卵泡刺激素(FSH)、黄体生成素(LH)和催乳素(PRL)含量测定。患者给予人绝经期促性腺激素(HMG)刺激卵巢,在卵泡抽吸前34-36小时阴道超声行人绒毛膜促性腺激素(HCG) 10000 IU诱导排卵。卵母细胞通过直接显微评价进行分类,将卵母细胞分为三组:第一组:前期;第二组。:中期I;第三组。:中期;卵泡液单胺和卵泡刺激素含量在卵母细胞成熟的不同阶段无显著差异。LH和PRL随卵母细胞成熟而显著升高(38.9;48.8;56.7 IU/l和1324;2382;3134 IU / l)。第一组5HT-LH呈显著负相关(r = -0.64);在第二组。NA-LH (r = -0.62)和NA-PRL (r = -0.51)之间的差异。FSH-LH在ⅰ组呈显著正相关(r = 0.63),在ⅱ组呈显著正相关(r = 0.63)。III组LH-PRL间差异(r = 0.56)。NA-5HT (r = 0.66)、NA-DA (r = 0.80)和5HT-DA (r = 0.66)之间的差异。这些观察结果表明,在卵母细胞成熟的最后阶段,LH和PRL的作用可能受到5HT和NA的负调节。
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