The feedsideward of cephalo-adrenal immune interactions.

Chronobiologia Pub Date : 1993-01-01
S Sánchez de la Peña
{"title":"The feedsideward of cephalo-adrenal immune interactions.","authors":"S Sánchez de la Peña","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The feedsideward phenomenon is the interaction of three or more rhythmic physiological entities by a diversified spectrum of rhythms that constitute a rhythmic network. These rhythmic units are: a) the modulator, b) the actor, c) the reactor and d) the integrative unity. Rhythmic interactions are characterized by an alternating sequence of algorithmically predictable effects of attenuation, no effect, and stimulation occurring in different frequencies. The basis of this phenomenon was determined from experimental evidence derived from cephalo-adrenal ex vivo studies. Internal phase-shift studies allow the demonstration ex vivo of a collateral hierarchy of rhythmic neuro-endocrine interactions as alpha, beta, gamma and delta rhythms. Linear least squares analyses describe and quantify circadian (alpha, beta and gamma) and infradian (delta) rhythms in the original series and the differences in responses [beta-alpha] and [gamma-delta]. These spontaneous and response rhythms reveal a collateral neuro-endocrine hierarchy and validate a pineal feedsideward phenomenon. Circadian-infradian murine rhythmic intermodulations are demonstrated in the epithelial corneal mitosis; brain neurosteroids and pineal melatonin content. A circadian rhythm in pineal melatonin content in female B6D2F1 mice and the chronomodulating action of melatonin + ACTH upon adrenal corticosterone production are confirmed. A chronopilot ex vivo study \"suggests\" that melatonin chronomodulates mouse aldosterone production. In a second chronopilot study, HrIL-2 chronomodulates rat corticosterone production ex vivo. Feedsidewards in vivo were seen in the chronomodulation of tumor-host balance occurring after melatonin, IL-2, cefodizime, and cyclosporine treatments that enhanced or delayed tumor growth and survival time of tumor-bearing mice.</p>","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"20 1-2","pages":"1-52"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronobiologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The feedsideward phenomenon is the interaction of three or more rhythmic physiological entities by a diversified spectrum of rhythms that constitute a rhythmic network. These rhythmic units are: a) the modulator, b) the actor, c) the reactor and d) the integrative unity. Rhythmic interactions are characterized by an alternating sequence of algorithmically predictable effects of attenuation, no effect, and stimulation occurring in different frequencies. The basis of this phenomenon was determined from experimental evidence derived from cephalo-adrenal ex vivo studies. Internal phase-shift studies allow the demonstration ex vivo of a collateral hierarchy of rhythmic neuro-endocrine interactions as alpha, beta, gamma and delta rhythms. Linear least squares analyses describe and quantify circadian (alpha, beta and gamma) and infradian (delta) rhythms in the original series and the differences in responses [beta-alpha] and [gamma-delta]. These spontaneous and response rhythms reveal a collateral neuro-endocrine hierarchy and validate a pineal feedsideward phenomenon. Circadian-infradian murine rhythmic intermodulations are demonstrated in the epithelial corneal mitosis; brain neurosteroids and pineal melatonin content. A circadian rhythm in pineal melatonin content in female B6D2F1 mice and the chronomodulating action of melatonin + ACTH upon adrenal corticosterone production are confirmed. A chronopilot ex vivo study "suggests" that melatonin chronomodulates mouse aldosterone production. In a second chronopilot study, HrIL-2 chronomodulates rat corticosterone production ex vivo. Feedsidewards in vivo were seen in the chronomodulation of tumor-host balance occurring after melatonin, IL-2, cefodizime, and cyclosporine treatments that enhanced or delayed tumor growth and survival time of tumor-bearing mice.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
头肾上腺免疫相互作用的馈向性。
馈向现象是三个或更多有节奏的生理实体通过构成节奏网络的多种节奏谱相互作用。这些节奏单位是:a)调制器,b)行动者,c)电抗器和d)综合统一体。节律性相互作用的特点是在不同频率上发生的算法可预测的衰减效应、无效应和刺激的交替序列。这种现象的基础是根据头肾上腺离体研究得出的实验证据确定的。内部相移研究允许在体外证明有节奏的神经内分泌相互作用的附属层次,如α, β, γ和δ节律。线性最小二乘分析描述并量化了原始序列中的昼夜节律(α, β和γ)和次弧度(δ)节律以及反应[β - α]和[γ - δ]的差异。这些自发和反应节律揭示了一个侧枝神经内分泌层次结构,并证实了松果体的馈向现象。小鼠在角膜上皮细胞有丝分裂中表现出昼夜节律互调;脑神经类固醇和松果体褪黑素含量。雌性B6D2F1小鼠松果体褪黑素含量的昼夜节律以及褪黑素+ ACTH对肾上腺皮质酮产生的时间调节作用得到证实。一项离体计时仪研究“表明”褪黑激素调节小鼠醛固酮的产生。在另一项时间先导研究中,HrIL-2在体外调节大鼠皮质酮的产生。在体内观察到,褪黑素、IL-2、头孢地嗪和环孢素治疗后,肿瘤-宿主平衡的时间调节可以增强或延迟荷瘤小鼠的肿瘤生长和生存时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Cardiovascular disease risk monitoring in the light of chronobioethics. Dora K. (Holly) Hayes. Agostino Carandente. Models for chronobiologic risk and prepathology detection. A tribute to Bill W. Kennedy. Cross-spectral coherence between geomagnetic disturbance and human cardiovascular variables at non-societal frequencies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1