Karyotype polymorphism and conserved characters in the Leishmania (Viannia) braziliensis complex explored with chromosome-derived probes.

J C Dujardin, N Gajendran, J Arevalo, A Llanos-Cuentas, H Guerra, J Gomez, J Arroyo, S De Doncker, D Jacquet, R Hamers
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引用次数: 0

Abstract

Molecular karyotype of 45 reference populations of Neotropical leishmanias was analyzed with ethidium bromide staining and with 6 chromosome-derived probes selected from a genomic library of Leishmania (Viannia) braziliensis. Size-conserved patterns were identified and found to be specific to subgenus Viannia and to its constitutive species. An important issue for epidemiology and clinical investigations was the discrimination between L. (V.) peruviana and L. (V.) braziliensis, 2 species found very similar by other genetic techniques, but responsible for totally different clinical patterns. The suggested existence of genetically distinct demes, or karyodemes, within the group-species might also show to be of importance, as these populations might differ in virulence, host-specificity and clinical manifestations.

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利用染色体衍生探针研究巴西利什曼原虫复合体的核型多态性和保守性。
采用溴化乙锭染色和从巴西利什曼原虫基因组文库中选择的6个染色体探针,对45个新热带利什曼原虫参考群体的分子核型进行了分析。鉴定并发现尺寸保守的模式是Viannia亚属及其组成种所特有的。秘鲁L. (V.)秘鲁L. (V.)巴西L. (V.)巴西ensis是流行病学和临床调查的一个重要问题,这两个物种通过其他遗传技术发现非常相似,但导致完全不同的临床模式。在类群物种中存在遗传上不同的核组可能也很重要,因为这些种群可能在毒力、宿主特异性和临床表现上有所不同。
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Diagnosis of amoebic infection of the liver: report of 36 cases. Diagnosis of pyogenic abscesses by ultrasound. [Impact of the introduction of a partogram on maternal and perinatal mortality. Study performed in a maternity clinic in Niameny, Niger]. [The method of cumulated amounts: a simple and efficient technique for epidemiological monitoring. Application to the epidemiological monitoring of malaria in the French Army in Gabon]. [Belgian tropical medicine is fully alive].
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