[The postradiation effect of noradrenaline, serotonin and dopamine on the activity of the Na-K pump in rat brain slices].

Abstract

Whole-body X irradiation with doses of 0.155 and 0.310 C/kg was shown to modify in different ways the activating effects of noradrenaline and serotonin, as well as a biphase effect of dopamine (5.10(-8)--1.5.10(-3) M) on Na,K-pump of neuronal membranes. The resulting effect was a function of a combination of radiation doses and neurotransmitter concentrations and thus showed different modes of interaction between neurotransmitter and ion-transport systems of brain cells in radiation sickness. The authors discuss possible molecular mechanisms of radiation modification of the functional interaction between the neurotransmitter and the active ion-transport systems in nerve cells.