M Blahová, J Sokolík, S Sedlácková, E Burianová, D Mlynarcík
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引用次数: 0
Abstract
The antimicrobial activities of a group of copper(II) chelates with the composition [Cu(TSB)(L)] or [Cu(TSB)(L')]. (TSB = N-salicylidene-L-alpha-alaninate dianion, L = imidazole and its alkyl derivatives, L' = pyrazole and 3,5-dimethylpyrazole) were studied. Bis-diazole complexes with L' = pyrazole and 3,5-dimethylpyrazole were found to be the most active against S. aureus (MIC = 78 and 20 micrograms.cm-3), less effective against C. albicans (156 micrograms.cm-3), T. terrestre and M. gypseum (100 micrograms.cm-3). The observed biological properties of complexes are discussed in relation to their proposed structures.
[Cu(TSB)(L)]或[Cu(TSB)(L’)]组成的铜(II)螯合物的抗菌活性。(TSB = n -水杨基-L- α -丙氨酸钠离子，L =咪唑及其烷基衍生物，L' =吡唑和3,5-二甲基吡唑)。双二唑与L′=吡唑和3,5-二甲基吡唑配合物对金黄色葡萄球菌(MIC分别为78和20 μ g .cm-3)的抑制作用最强，对白色念珠菌(MIC分别为156 μ g .cm-3)、地霉和石膏分枝杆菌(MIC分别为100 μ g .cm-3)的抑制作用较弱。对观察到的配合物的生物学性质及其提出的结构进行了讨论。
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