Fetal and neonatal action of a polycyclic hydrocarbon (benzpyrene) or a synthetic steroid hormone (allylestrenol) as reflected by the sexual behaviour of adult rats.

Journal of developmental physiology Pub Date : 1993-02-01
G Csaba, C Karabélyos, J Dalló
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Abstract

Allylestrenol or benzpyrene, given either between the 15th and 19th days of fetal life or from birth to the postnatal 7th day, caused dramatic decrease in the sexual activity of adult female rats. Allylestrenol, given in fetal life, resulted in a profound increase in the sexual activity of male rats. Given in newborn conditions, a decrease of sexual activity was caused by the same chemical. Considering, that one of the molecules has importance in medical practice and the other is an environmental pollutant, the experiments forecast the probability of modification in the sexual behaviour of human adults.

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多环烃(苯并芘)或合成类固醇激素(烯丙烯雌醇)对胎儿和新生儿的作用,反映在成年大鼠的性行为上。
烯丙雌醇或苯并芘在胎龄第15 ~ 19天或出生后至产后7天给予,可显著降低成年雌性大鼠的性活动。在胎儿时期给予烯丙烯雌醇,导致雄性大鼠的性活动显著增加。在新生儿条件下,性活动的减少是由同样的化学物质引起的。考虑到其中一种分子在医疗实践中具有重要意义,另一种分子是环境污染物,实验预测了人类成人性行为改变的可能性。
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