A T Ozçelikay, V M Altan, N Yildizoğlu-Ari, O Altinkurt, F Onur, Y Oztürk
{"title":"Basal and histamine-induced gastric acid secretion in alloxan diabetic rats.","authors":"A T Ozçelikay, V M Altan, N Yildizoğlu-Ari, O Altinkurt, F Onur, Y Oztürk","doi":"10.1016/0306-3623(93)90021-o","DOIUrl":null,"url":null,"abstract":"<p><p>1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach.</p>","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(93)90021-o","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/0306-3623(93)90021-o","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
Abstract
1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach.