Basal and histamine-induced gastric acid secretion in alloxan diabetic rats.

A T Ozçelikay, V M Altan, N Yildizoğlu-Ari, O Altinkurt, F Onur, Y Oztürk
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引用次数: 17

Abstract

1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach.

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四氧嘧啶糖尿病大鼠胃酸分泌的基础和组胺诱导。
1. 四氧嘧啶诱导的糖尿病对大鼠胃酸分泌的影响采用了前面描述的一些生物统计学模型。2. 四氧嘧啶糖尿病大鼠与同龄对照组相比,组胺诱导的胃酸分泌减少。3.根据实验诱导的糖尿病,基底酸分泌也减少。4. 上述结果强烈提示四氧嘧啶诱导的糖尿病抑制胃迷走神经活性和h2受体活性。
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