[The antiradiation action of 6-methyluracil].

Radiobiologiia Pub Date : 1993-03-01

Iu P Taran, L N Shishkina

引用次数: 0

Abstract

A single dose of 6-methyluracil (50 mg/kg) administered intraperitoneally to BALB and SHK mice prior to X irradiation (5.0 Gy) produced a pronounced radioprotective effect which was dependent upon the initial antioxidant status of the body, but independent of the effect of the agent on postirradiation leukopenia dynamics. The radioprotective effect of 6-methyluracil was conditioned by its influence on lipid peroxidation regulation and was displayed by the normalization of the antioxidant activity of lipids of radiosensitive organs and tissues and by high activity of superoxide dismutase in the liver and erythrocytes.

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[6-甲基尿嘧啶的抗辐射作用]。

在X射线(5.0 Gy)照射前给BALB和SHK小鼠腹腔注射单剂量的6-甲基尿嘧啶(50 mg/kg)，产生明显的辐射防护作用，这取决于机体的初始抗氧化状态，但与该剂对辐射后白细胞减少动力学的影响无关。6-甲基尿嘧啶的辐射防护作用以其对脂质过氧化调节的影响为条件，并表现为放射敏感器官和组织脂质抗氧化活性的正常化以及肝脏和红细胞超氧化物歧化酶的高活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Radiobiologiia

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