Does reserpine induce parkinsonian rigidity?

E Lorenc-Koci, K Ossowska, J Wardas, S Wolfarth
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引用次数: 36

Abstract

The aim of the study was to find out whether the reserpine-induced rigidity is similar to that seen in parkinsonism. Simultaneous measurements of the muscle resistance of the hind foot to passive bending and stretching in the ankle joint, as well as of the electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles of rats were carried out. Reserpine was injected in a dose of 10 mg/kg alone or with alpha-methyl-p-tyrosine (250 mg/kg) 1, 4 and 27.5 h before the measurements. Reserpine increased the muscle resistance of the rat's hind leg to passive movements. That effect was the strongest at 1-2 h after the injections, and diminished markedly afterwards. The rigidity was accompanied with an increase in the resting, as well as in the stretch-induced short- and long-latency EMG activity in the gastrocnemius muscle. However, the intensity of the latter symptom did not change for a long period of time, which seems to correlate with the striatal dopamine depletion. The results suggest that the reserpine-increased EMG activity is a good model of parkinsonian rigidity.

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利血平会诱发帕金森性僵硬吗?
这项研究的目的是找出利血平引起的僵硬是否与帕金森症相似。同时测量大鼠后脚对踝关节被动弯曲和拉伸的肌肉阻力,以及腓肠肌和胫骨前肌的肌电图(EMG)活动。利血平在测量前1、4和27.5小时单独注射10 mg/kg或与α -甲基-对酪氨酸(250 mg/kg)一起注射。利血平增加了大鼠后腿对被动运动的肌肉阻力。这种效果在注射后1-2小时最强,注射后明显减弱。刚性伴随着静息的增加,以及拉伸引起的腓肠肌短潜伏期和长潜伏期肌电图活动的增加。然而,后一种症状的强度在很长一段时间内没有改变,这似乎与纹状体多巴胺消耗有关。结果表明,利血平增加肌电活动是帕金森病刚性的良好模型。
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