{"title":"Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation","authors":"Teresa Viganò , Alicia Hernandez , Alberto Corsini , Agnese Granata , Pierangelo Belloni , Remo Fumagalli , Rodolfo Paoletti , Giancarlo Folco","doi":"10.1016/0922-4106(95)90143-4","DOIUrl":null,"url":null,"abstract":"<div><p>The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC<sub>50</sub> value of 0.97±0.1 <em>μ</em>M. Mevalonate (100 μM), as well as geranylgeraniol (5 μM), at their highest non-toxic concentrations, restored cell proliferation to control levels.</p></div>","PeriodicalId":100502,"journal":{"name":"European Journal of Pharmacology: Molecular Pharmacology","volume":"291 2","pages":"Pages 201-203"},"PeriodicalIF":0.0000,"publicationDate":"1995-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0922-4106(95)90143-4","citationCount":"21","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pharmacology: Molecular Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0922410695901434","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 21
Abstract
The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97±0.1 μM. Mevalonate (100 μM), as well as geranylgeraniol (5 μM), at their highest non-toxic concentrations, restored cell proliferation to control levels.
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