Changes in contractile function with low-osmolal and isosmolal contrast media for coronary angiography.

Acta radiologica. Supplementum Pub Date : 1995-01-01 DOI:10.1177/0284185195036s39916

H Blankson, T Holten, A N Oksendal, P Jynge

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引用次数: 8

Abstract

Changes in contractile function induced by modern roentgen contrast media (CM) were examined in isolated rat hearts. Four coronary perfusions were undertaken in each heart with increasing volumes of each CM in order to test a wider spectrum of potential side-effects. Left ventricular developed pressure (LVDP) and heart rate (HR) were recorded. Six commercially available or investigational CM were examined: A, Hexabrix (ioxaglate 320 mg I/ml, Na 146 mM); B, Iosvist (iotrolan 300 mg I/ml, Na 6 mM);C, Visipaque (iodixanol 320 mg I/ml, Na 19 mM, Ca 0.3 mM); D, "Iodixanol high Ca-Mg" (iodixanol 320 mg I/ml, Na 19 mM, Ca 1.2 mM, Mg 0.6 MM); E, "Iohexol I 350" (iohexol 350 mg I/ml, Na 28 mM); and F, "Iohexol I 150" (iohexol 150 mg I/ml Na 28 mM). A, E and F were low-osmolal (400-940 mosm/kg H2O) CM whereas B, C and D were essentially isosmolal. Contractile changes (transient LVDP depression) was volume-dependent. Maximal values for LVDP depression were "Iohexol I 150" 11-22%

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低渗透压和等渗透压造影剂对冠状动脉造影收缩功能的影响。

研究了现代x射线造影剂(CM)对离体大鼠心脏收缩功能的影响。在每个心脏进行四次冠状动脉灌注，增加每个CM的容量，以测试更广泛的潜在副作用。记录左心室发育压(LVDP)和心率(HR)。检测了六种市售或研究性CM: A, Hexabrix (ioxagate 320 mg I/ml, Na 146 mM);B, Iosvist (iotrolan 300 mg I/ml, Na 6 mM);C, Visipaque(碘沙醇320 mg I/ml, Na 19 mM, Ca 0.3 mM);D，“碘沙醇高Ca- mg”(碘沙醇320 mg I/ml, Na 19 mM, Ca 1.2 mM, mg 0.6 mM);E，“Iohexol I 350”(Iohexol 350 mg I/ml, Na 28 mM);F，“Iohexol I 150”(Iohexol 150 mg I/ml Na 28 mM)。A、E和F是低渗透压(400-940 mosm/kg H2O) CM，而B、C和D基本上是等渗透压CM。收缩变化(瞬时LVDP下降)与体积有关。LVDP抑制的最大值为“Iohexol I 150”11-22%

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Acta radiologica. Supplementum

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