Resistance mechanisms in human lung cancer.

Invasion & metastasis Pub Date : 1995-01-01
J Mattern, M Volm
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Abstract

Drug resistance is an important problem in the treatment of lung cancer. Patients become resistant not only to the drugs used initially, but also to those to which they have not yet been exposed. Multiple mechanisms contribute to drug resistance in this disease, all or any combination of which may occur simultaneously within each cell, producing an overall drug-resistant phenotype. The limited success of hitherto applied strategies in their ability to circumvent drug resistance in lung cancer suggests that new approaches are required.

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人肺癌的耐药机制。
耐药是肺癌治疗中的一个重要问题。患者不仅对最初使用的药物产生耐药性,而且对尚未接触过的药物也产生耐药性。多种机制有助于这种疾病的耐药,所有或任何组合可能在每个细胞内同时发生,产生总体耐药表型。迄今为止应用的策略在规避肺癌耐药方面的有限成功表明,需要新的方法。
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