Dissociation constants of water-insoluble carboxylic acids by 13C-NMR. pK(a)s of mesobiliverdin-XIII alpha and mesobilirubin-XIII alpha.

Experientia Pub Date : 1996-06-15 DOI:10.1007/BF01969747
D A Lightner, D L Holmes, A F McDonagh
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引用次数: 3

Abstract

High-field 13C-NMR of 13C-enriched compounds in dilute aqueous d6-Me2-SO solutions provides a simple, accurate method for measuring pK(a)s of sparingly soluble carboxylic acids. Using this method, we found the pK(a)s of mesobilirubin-XIII alpha to be 4.2 and 4.9, much lower values than reported recently for bilirubin, and of mesobiliverdin-XIII alpha to be 3.9 and 5.3.

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水不溶性羧酸的13C-NMR解离常数。中胆红素- xiii α和中胆红素- xiii α的pK(a)s。
在稀水d6-Me2-SO溶液中富集13c的化合物的高场13C-NMR为测定难溶羧酸的pK(a)s提供了一种简单、准确的方法。利用这种方法,我们发现中胆红素- xiii α的pK(a)s为4.2和4.9,远低于最近报道的胆红素,中胆红素- xiii α的pK(a)s为3.9和5.3。
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