H Haraguchi, I Ohmi, H Masuda, Y Tamura, K Mizutani, O Tanaka, W H Chou
{"title":"Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes.","authors":"H Haraguchi, I Ohmi, H Masuda, Y Tamura, K Mizutani, O Tanaka, W H Chou","doi":"10.1007/BF01969729","DOIUrl":null,"url":null,"abstract":"<p><p>Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against both dl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.</p>","PeriodicalId":12087,"journal":{"name":"Experientia","volume":"52 6","pages":"564-7"},"PeriodicalIF":0.0000,"publicationDate":"1996-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01969729","citationCount":"20","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experientia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF01969729","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 20
Abstract
Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against both dl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.
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