Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi.

Experientia Pub Date : 1996-06-15 DOI:10.1007/BF01969731

H Haraguchi, H Ishikawa, S Sakai, B P Ying, I Kubo

引用次数: 3

Abstract

A diterpenoid, totarol (1), from Podocarpus nagi was evaluated as an antioxidant. This diterpenoid inhibited autoxidation of linoleic acid. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited. Nagilactone E (2), a norditerpene lactone isolated from the same source, had no antioxidative activity. Furthermore, totarol protected red cells against oxidative hemolysis. This diterpene was shown to be effective in protecting biological systems against oxidative stresses.

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龙柏二萜对脂质过氧化的抑制作用。

一种二萜类化合物——龙桃醇(1)被评价为抗氧化剂。这种二萜抑制亚油酸的自氧化。Fe(III)-ADP/NADH或Fe(III)-ADP/NADPH诱导的线粒体和微粒体脂质过氧化也被抑制。Nagilactone E(2)，一种从同一来源分离的去二萜内酯，没有抗氧化活性。此外，紫杉醇还能保护红细胞免受氧化性溶血。这种二萜被证明在保护生物系统免受氧化应激方面是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Experientia

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