Oxygen sensing in the carotid body.

C Gonzalez, I Vicario, L Almaraz, R Rigual
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引用次数: 19

Abstract

In the present article we review in a concise manner the literature on the mechanisms of O2 chemoreception in the carotid body of adult mammals. In the first section we describe the basic structure of the carotid body, and define this organ as a secondary sensory receptor. In the second section is presented the most relevant literature on the O2 metabolism in the carotid body to define the parameters of O2 chemoreception, including hypoxic thresholds and P50 of the hypoxic responses. The final section is devoted to the mechanisms of detection of the hypoxic stimulus. We provide the data in favor and against each of the current three models on O2 chemoreception: the membrane model, the metabolic hypothesis with its different versions and the NAD(P)H oxidase model.

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颈动脉体的氧感应。
在本文中,我们简要回顾了关于成年哺乳动物颈动脉体氧化学接受机制的文献。在第一部分中,我们描述了颈动脉体的基本结构,并将该器官定义为二级感觉受体。第二部分介绍了颈动脉体内氧代谢的最相关文献,定义了氧化学接受的参数,包括缺氧阈值和缺氧反应的P50。最后一节讨论了检测缺氧刺激的机制。我们提供了支持和反对目前三种O2化学接受模型的数据:膜模型,代谢假说及其不同版本和NAD(P)H氧化酶模型。
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