Intravenous anaesthetic drug interactions: practical applications.

H R Vinik
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Abstract

The spectrum of effects that constitutes the state of general anaesthesia can be induced by the combined use of drugs. Each drug has a predominant action regarding one of the anaesthesia components, hypnosis, analgesia and amnesia. However, each agent, when used in combination, not only produces its own expected effect, but it can also modify the effect of another agent acting on a different component. For example, an opioid, in addition to its anti-nociceptive effect, can also potentiate the hypnotic effect of a benzodiazepine. Anaesthetists have long recognized these effects but did not quantify them until recently. Pharmacologists have provided us with techniques to measure drug interactions. We have utilized these techniques to demonstrate and quantify significant pharmacological interactions for hypnotic effect with commonly used intravenous agents. The clinical utility of these combinations can now be exploited precisely for the benefit of all our patients.

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静脉麻醉药物相互作用:实际应用。
构成全身麻醉状态的一系列效应可由药物联合使用引起。每种药物对麻醉成分之一,催眠,镇痛和健忘症有主要作用。然而,每种药物在联合使用时,不仅能产生其自身的预期效果,而且还能改变另一种药物作用于不同成分时的效果。例如,阿片类药物除了具有抗伤害作用外,还可以增强苯二氮卓类药物的催眠作用。麻醉师很早就认识到这些影响,但直到最近才量化它们。药理学家为我们提供了测量药物相互作用的技术。我们利用这些技术来证明和量化催眠效果与常用静脉注射药物的显著药理相互作用。这些组合的临床效用现在可以被精确地利用来造福我们所有的病人。
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