[The effect of many years of hemodialysis therapy on hypophyseal-gonadal axis function in males with chronic renal insufficiency].

Abstract

The study aims at evaluating an effect of hemodialyses duration on LH, FSH, and testosterone secretion in males with chronic renal insufficiency. Secretion of these hormones was assessed with LH-RH stimulation test in 41 men with chronic renal insufficiency and 15 healthy controls. Increased LH and FSH and decreased testosterone serum levels were seen in men with chronic renal insufficiency in comparison with healthy controls, independently of hemodialysis therapy duration. Duration of the treatment with hemodialyses has no significant effect on LH levels. Testosterone and FSH levels were significantly higher in patients treated over 50 months than those treated for shorter periods. Reactivity of LH secretion in LH-RH stimulation test was lower in patients dialysed for less than 100 months whereas in patients dialysed for over 100 months it was normal. Reactivity of testosterone secretion was higher in patients dialysed for over 50 months that those dialysed for shorter periods of time.