Ursodeoxycholic acid in the treatment of primary sclerosing cholangitis.

Abstract

Ursodeoxycholic acid treatment used in the management of primary sclerosing cholangitis leads to a rapid improvement in liver enzymes and is well tolerated in most patients. Fatigue and pruritus also showed an improvement, even if not significant compared with placebo, in some 50% of cases. Results of the investigations also showed that liver transplantation may be postponed in primary sclerosing cholangitis treated with ursodeoxycholic acid.