A. Fučić , D. Barković , Verica Garaj-Vrhovac , D. Kubelka , B. Ivanic , T. Dabo , A. Mijić
{"title":"A nine-year follow up study of a population occupationally exposed to vinyl chloride monomer","authors":"A. Fučić , D. Barković , Verica Garaj-Vrhovac , D. Kubelka , B. Ivanic , T. Dabo , A. Mijić","doi":"10.1016/S0165-1161(96)90229-0","DOIUrl":null,"url":null,"abstract":"<div><p>The presence of structural chromosome aberrations and sister chromatid exchange frequencies (SCE) were studied in lymphocytes from 28 male subjects occupationally exposed to vinyl chloride monomer for a period of 9 years. A significant increase in chromosomal damages and elevated SCE frequencies was detected during the third and fourth year of the follow-up study. During the last 2 years, all examined parameters are approaching control values. This is a result of decreasing vinyl chloride monomer concentrations in the working environment without interrupting the working process.</p></div>","PeriodicalId":18870,"journal":{"name":"Mutation Research\\/environmental Mutagenesis and Related Subjects","volume":"361 1","pages":"Pages 49-53"},"PeriodicalIF":0.0000,"publicationDate":"1996-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0165-1161(96)90229-0","citationCount":"32","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research\\/environmental Mutagenesis and Related Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165116196902290","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 32
Abstract
The presence of structural chromosome aberrations and sister chromatid exchange frequencies (SCE) were studied in lymphocytes from 28 male subjects occupationally exposed to vinyl chloride monomer for a period of 9 years. A significant increase in chromosomal damages and elevated SCE frequencies was detected during the third and fourth year of the follow-up study. During the last 2 years, all examined parameters are approaching control values. This is a result of decreasing vinyl chloride monomer concentrations in the working environment without interrupting the working process.