Chromosomal aberration analysis in 85 control individuals

E. Carbonell , F. Peris , N. Xamena , A. Creus , R. Marcos
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引用次数: 12

Abstract

Chromosomal aberrations (CA) were studied in the peripheral blood lymphocytes of 85 healthy male volunteers from Barcelona (Catalonia, Spain). The effect that factors such as age, life style, work exposure and medical treatment had on the cytological endpoints was studied by means of a Poisson regression model. The results obtained indicate a significant positive relationship between the age of the subjects analyzed and the total of chromosome-type aberrations. With respect to the other variables analyzed, a positive association was found between the frequent consumption of analgesics and the incidence of chromatid-type aberrations.

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85例对照者染色体畸变分析
本文研究了来自西班牙巴塞罗那85名健康男性志愿者外周血淋巴细胞的染色体畸变(CA)。采用泊松回归模型研究年龄、生活方式、工作暴露、医疗等因素对细胞学终点的影响。得到的结果表明,被分析对象的年龄与染色体型畸变总数之间存在显著的正相关关系。在分析其他变量时,发现频繁使用镇痛药与染色单体畸变发生率呈正相关。
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