Anna Petroni, Milena Blasevich, Patrizia La Spada, Nadia Papini, Claudio Galli
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引用次数: 2
Abstract
SK-N-BE cells were differentiated (D) to neurons with retinoic acid. Total n - 6 polyunsaturated fatty acids (PUFA), especially arachidonic acid (AA), were increased in D versus ND cells. AA synthesis from linoleic acid (LA) and phospholipid (PL) synthesis from glycerol were initially elevated, whereas both processes were reduced approaching differentiation. At this stage, the incorporation of glycerol in triglycerides was enhanced. Formation of long chain PUFA and synthesis of acceptors (PL) for esterification, during RA-induced SK-N-BE differentiation, appear to be associated.
k - n - be细胞在维甲酸作用下分化为神经元(D)。总n - 6多不饱和脂肪酸(PUFA)，特别是花生四烯酸(AA)在D和ND细胞中增加。从亚油酸(LA)合成AA和从甘油合成磷脂(PL)最初升高，但在接近分化时，这两个过程都减少了。在这个阶段，甘油在甘油三酯中的掺入增强。在ra诱导的SK-N-BE分化过程中，长链PUFA的形成和酯化受体(PL)的合成似乎是相关的。
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