{"title":"Transrearrangements as biomarkers for risk of lymphoid malignancy.","authors":"I R Kirsch, F Lista","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In this chapter we describe an assay for lymphocyte specific antigen receptor transrearrangements mediated by the V(D)J recombinase complex. Such transrearrangements occur in all normal individuals, are capable of increasing the immune repertoire and can be viewed as a readily available baseline measure of a type of genetic instability. In human and murine systems, the absolute number of some of these transrearrangements correlates at the population level with risk for the development of lymphoid malignancy.</p>","PeriodicalId":77062,"journal":{"name":"Cancer surveys","volume":"28 ","pages":"311-27"},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer surveys","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In this chapter we describe an assay for lymphocyte specific antigen receptor transrearrangements mediated by the V(D)J recombinase complex. Such transrearrangements occur in all normal individuals, are capable of increasing the immune repertoire and can be viewed as a readily available baseline measure of a type of genetic instability. In human and murine systems, the absolute number of some of these transrearrangements correlates at the population level with risk for the development of lymphoid malignancy.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
