{"title":"Repression of the 5-lipoxygenase gene by c-myb overexpression in differentiated HL-60 cells","authors":"André Ponton , Jean-Paul Thirion , Pierre Siroie","doi":"10.1016/S0090-6980(96)00140-2","DOIUrl":null,"url":null,"abstract":"<div><p>This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds, the 5-lipoxygenase promoter in undifferentiated cells but not in DMSQ-diif ferentiated cells. Also, we show that overexpression of <em>c-myb</em> cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.</p></div>","PeriodicalId":20653,"journal":{"name":"Prostaglandins","volume":"53 1","pages":"Pages 49-58"},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0090-6980(96)00140-2","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0090698096001402","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16
Abstract
This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds, the 5-lipoxygenase promoter in undifferentiated cells but not in DMSQ-diif ferentiated cells. Also, we show that overexpression of c-myb cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.
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