Herpesviruses and AIDS.

P D Griffiths
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引用次数: 0

Abstract

It is well recognized clinically that herpesviruses can cause disease in AIDS patients once human immunodeficiency virus (HIV) has precipitated marked immunosuppression. However, in addition to this opportunistic relationship, there is evidence to suggest that herpesviruses could increase the pathogenicity of HIV by acting as cofactors. Experiments in vitro have shown that several herpesviruses can activate HIV gene expression or alter the cellular tropism of HIV through a variety of mechanisms (antigen presentation, cytokine release, pseudotype formation, CD4 cell surface upregulation, Fc receptor formation, transactivation). Studies of human autopsy material have shown that some herpesviruses (particularly cytomegalovirus, human herpes virus 6 and herpes simplex virus) are found frequently in AIDS patients. If such herpesviruses act as cofactors in vivo, then their inhibition by aciclovir could explain why a survival benefit has been reported from the use of this drug in two double-blind, placebo-controlled randomized trials.

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疱疹病毒和艾滋病。
临床已经充分认识到,一旦人类免疫缺陷病毒(HIV)引起明显的免疫抑制,疱疹病毒就可以引起艾滋病患者的疾病。然而,除了这种机会性关系之外,有证据表明疱疹病毒可以通过作为辅助因子来增加HIV的致病性。体外实验表明,几种疱疹病毒可通过多种机制(抗原呈递、细胞因子释放、伪型形成、CD4细胞表面上调、Fc受体形成、反激活)激活HIV基因表达或改变HIV的细胞向性。人体解剖材料的研究表明,一些疱疹病毒(特别是巨细胞病毒、人类疱疹病毒6和单纯疱疹病毒)在艾滋病患者中经常被发现。如果这些疱疹病毒在体内作为辅助因子,那么阿昔洛韦对它们的抑制作用可以解释为什么在两个双盲、安慰剂对照的随机试验中,使用这种药物可以提高生存率。
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Annual disease burden due to human papillomavirus (HPV) 6 and 11 infections in Finland. Annual disease burden due to human papillomavirus 16 and 18 infections in Finland. HIV viral resistance to antiretroviral drugs: foreword. Use of genotypic assays for the detection of antiretroviral resistance: a legal proceeding, Rome, 22-23 April 2002. Viral resistance to chemotherapeutic agents: an expectable unexpected phenomenon.
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