C Voiculescu, C Avramescu, E Radu, M Bălăşoiu, A Turculeanu
{"title":"Blood amounts and suppressive in vitro activity of CD8+11b(+)-lymphocytes from HIV-infected children, related to hepatitis B or C virus association.","authors":"C Voiculescu, C Avramescu, E Radu, M Bălăşoiu, A Turculeanu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In HIV only, as well as in HIV/hepatitis B- and HIV/hepatitis C-infected children (6 to 8 years of age), with moderate altered clinical and immune cell markers, the total amounts of CD8(+)-set and of CD8+11b(+)-subset (T-suppressor) blood lymphocytes, by means of flow cytometry, were determined. On the other hand, within several mixtures of autologous sorted CD3+/CD8+11b(+)-cells, the per cent reduction of HLA-DR+ expression on T-cells, at different effector/responder cell ratios, was appreciated. Significant higher levels of CD8+11b(+)-cells, especially in HIV/hepatitis B virus groups, were found, that correlated with a stronger suppressive activity. The strongest alteration of immune markers, within HIV-seropositive, HBs+, HBe+ patients, was noticed. A possible usefulness of these data in HIV only, and in HIV-associated hepatitis B or C virus contamination, during pediatric AIDS monitoring, was commented.</p>","PeriodicalId":79532,"journal":{"name":"Romanian journal of virology","volume":"46 3-4","pages":"171-8"},"PeriodicalIF":0.0000,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian journal of virology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In HIV only, as well as in HIV/hepatitis B- and HIV/hepatitis C-infected children (6 to 8 years of age), with moderate altered clinical and immune cell markers, the total amounts of CD8(+)-set and of CD8+11b(+)-subset (T-suppressor) blood lymphocytes, by means of flow cytometry, were determined. On the other hand, within several mixtures of autologous sorted CD3+/CD8+11b(+)-cells, the per cent reduction of HLA-DR+ expression on T-cells, at different effector/responder cell ratios, was appreciated. Significant higher levels of CD8+11b(+)-cells, especially in HIV/hepatitis B virus groups, were found, that correlated with a stronger suppressive activity. The strongest alteration of immune markers, within HIV-seropositive, HBs+, HBe+ patients, was noticed. A possible usefulness of these data in HIV only, and in HIV-associated hepatitis B or C virus contamination, during pediatric AIDS monitoring, was commented.