{"title":"Aging, immunity and neuroendocrine hormones","authors":"R. Lee Mosley","doi":"10.1016/S0960-5428(97)00031-9","DOIUrl":null,"url":null,"abstract":"<div><p>Recent evidence indicates that the neuroendocrine and immune systems are intimately integrated into one system that provides a complex homeostatic network. Disruption of one system by extrinsic factors such as stress or antigenic exposure usually has consequences on the other. With advancing age, a progressive disruption can be observed in both systems which may have profound implications with respect to age-associated pathologies, including autoimmunity. In this review evidence is summarized which supports the hypothesis that neuroendocrine factors influence the age-associated decline of the immune system.</p></div>","PeriodicalId":79314,"journal":{"name":"Advances in neuroimmunology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0960-5428(97)00031-9","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in neuroimmunology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0960542897000319","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
Abstract
Recent evidence indicates that the neuroendocrine and immune systems are intimately integrated into one system that provides a complex homeostatic network. Disruption of one system by extrinsic factors such as stress or antigenic exposure usually has consequences on the other. With advancing age, a progressive disruption can be observed in both systems which may have profound implications with respect to age-associated pathologies, including autoimmunity. In this review evidence is summarized which supports the hypothesis that neuroendocrine factors influence the age-associated decline of the immune system.
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