How to manage drug interactions.

P S Glass, S Howell, T J Gan, B Ginsberg
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引用次数: 3

Abstract

Multiple drugs are used to provide anaesthesia. On average, four to six drugs are used during anaesthesia and, therefore, drug interactions are common. These interactions are primarily either pharmacokinetic or pharmacodynamic. Due to the relatively short duration of drug administration for anaesthesia, pharmacokinetic drug interactions resulting from alterations in drug metabolism do not generally produce clinically significant effects. Pharmacodynamic-drug interactions between anaesthetic drugs, however, are potentially serious. This may reflect that anaesthesia is not a single entity, but a process provided by a combination of drugs; i.e. loss of consciousness, analgesia and neuromuscular blockade. An understanding of each drug's pharmacokinetics, pharmacodynamics and drug interactions will allow clinicians to administer drugs to provide a more optimal anaesthetic.

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如何管理药物相互作用。
使用多种药物进行麻醉。在麻醉期间平均使用四到六种药物,因此药物相互作用是常见的。这些相互作用主要是药代动力学或药效学。由于麻醉给药时间相对较短,由药物代谢改变引起的药代动力学药物相互作用通常不会产生显著的临床效应。然而,麻醉药物之间的药效学-药物相互作用是潜在的严重问题。这可能反映了麻醉不是一个单一的实体,而是由药物组合提供的过程;即意识丧失,镇痛和神经肌肉阻滞。了解每种药物的药代动力学、药效学和药物相互作用将使临床医生能够给药,提供更理想的麻醉剂。
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