Bacterial lipopolysaccharide induces diarrhoea in caecectomized mice.

F S Robert, J P Rao
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Abstract

Castor oil, lipopolysaccharide of Escherichia coli, and endotoxin of Salmonella typhimurium were used for inducing diarrhoea in sham operated or caecectomized mice. Copious diarrhoea was induced by lipopolysaccharide (LPS) in caecectomized mice. Characteristics of diarrhoea induced by castor oil were not different between the two groups. It is concluded that caecectomized mice may be a good model to study lipopolysaccharide-induced diarrhoea.

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细菌脂多糖诱导阉割小鼠腹泻。
用蓖麻油、大肠杆菌脂多糖和鼠伤寒沙门菌内毒素诱导假手术或切除盲肠小鼠腹泻。脂多糖(LPS)诱导小鼠大量腹泻。蓖麻油引起的腹泻特征在两组间无显著差异。由此可见,腹腔切除小鼠可能是研究脂多糖性腹泻的良好模型。
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