{"title":"Synthesis of azaalanine peptides using the solid phase method.","authors":"C J Gray, N I Desai, R Gorst, G Masih","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The methodology for the incorporation of azaamino-acid residues into peptides synthesised by a solid-phase method has been extended to allow azaalanine peptides to be prepared. In this way, Ac-Leu-Ser-Gly-azaAla-Gly-Phe-Ser-Leu-NH2 H-Ala-Ala-Lys-Glu-Ala-Ala-Glu-Ala -Ala-Glu-Lys-Ala-azaAla-Glu-Leu-Ala-Leu-N2H3, and H-Ala-azaAla-Lys-Glu-Ala-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Glu-Leu-A la-Leu-N2H3 have been prepared. A new analogue of the Ala-Gly sequence, 3-azaalanylpropionic acid has been prepared and used to prepare the peptide analogue acetyl-Leu-Ser-Gly-azaAla-3-Prop-Phe-Ser-Leu-NH2.</p>","PeriodicalId":8980,"journal":{"name":"Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity","volume":"2 1","pages":"13-8"},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The methodology for the incorporation of azaamino-acid residues into peptides synthesised by a solid-phase method has been extended to allow azaalanine peptides to be prepared. In this way, Ac-Leu-Ser-Gly-azaAla-Gly-Phe-Ser-Leu-NH2 H-Ala-Ala-Lys-Glu-Ala-Ala-Glu-Ala -Ala-Glu-Lys-Ala-azaAla-Glu-Leu-Ala-Leu-N2H3, and H-Ala-azaAla-Lys-Glu-Ala-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Glu-Leu-A la-Leu-N2H3 have been prepared. A new analogue of the Ala-Gly sequence, 3-azaalanylpropionic acid has been prepared and used to prepare the peptide analogue acetyl-Leu-Ser-Gly-azaAla-3-Prop-Phe-Ser-Leu-NH2.
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